ENDOR References & Articles • Peribio Skincare

The image shows the 3D topometric profile of a volunteer after using the Serum for 28 days. There is a reduction of 54% of the peeks and valleys that form the wrinkles resulting in a younger healthier-looking skin.

improves the appearance of wrinkles, skin texture and firmness, showing an outstanding efficacy due to its high active concentration.

Anti-aging Serum with AuHA™

The Science

The unique nano gold technology that is present in all Endor Technologies skincare products boosts the natural revitalisation of skin at the cellular level. The nano gold technology is made by uniting tiny fragments of hyaluronic acid with tiny particles of gold that are so small they are able to enter the skin dermis and activate multiple cell receptors, stimulating the natural production of hyaluronic acid, collagen and elastin; which over time results in smoother, firmer, healthier skin reducing cellulite and signs of aging.

Articles & Studies

In Use Efficacy of Serum and Cream Containing HA-Conjugated Gold Nanocomplexes to Increase the Synthesis of the Epidermal Extracellular Matrix and Improve the Skin Condition.

In use double blind, randomized, placebocontrolled efficacy test of a cream to reduce the cellulite effects and increase the skin antioxidants.

In use double blind, randomized, placebocontrolled efficacy test of a serum with gold nanocomplexes combined with radiofrequency to reduce the cellulite effects.

In use, randomized, active-controlled efficacy test of a post-fractional laser cream with gold nanocomplexes to improve wound healing and reduce adverse effects.

In Vitro Safety Toxicology Data for Evaluation of Gold Nanoparticles–Chronic Cytotoxicity, Genotoxicity and Uptake

Bibliography

Stern R (2004). “Hyaluronan catabolism: a new metabolic pathway”. Eur. J. Cell Biol. 83 (7): 317–25.

Ghatak S et el. (2015) “Roles of Proteoglycans and Glycosaminoglycans in Wound Healing and Fibrosis”. Int. J. Cell Biol. Article 834893, 20 pages.

Cyphert et al (2015). ”Size Matters: molecular Weight Specificity of Hyaluronic Effects in Cell Biology”. Int. J. Cell Biol. Article 563818, 8 pages.

Ghazi et el. (2012). “Hyaluron Fragment Improve Wound Healing …”. Plus One. Vol 7, Issue 11, e48351.

Guglielmoa C, et al. “Embryotoxicity of cobalt ferrite and gold nanoparticles: A first in vitro approach. Reproductive Toxicology 30 (2010) 271–276.

Guglielmoa C, et al. “In Vitro Safety Toxicology Data for Evaluation of Gold Nanoparticles–Chronic Cytotoxicity, Genotoxicity and Uptake”. Journal of Nanoscience and Nanotechnology. Vol. 12, 6185–6191, 2012.

Aya KL, Stern R. “Hyaluronan in wound healing: Rediscovering a major player”. Wound Rep Reg (2014) 22 579–593, 2014.

Litwiniuk M, Krejner A, Grzela T. “Hyaluronic Acid in Inflammation and Tissue Regeneration”. Wounds 2016;28(3):78-88.

Lilly Y.W. Bourguignon. “Matrix Hyaluronan-Activated CD44 Signaling Promotes Keratinocyte Activities and Improves Abnormal Epidermal Functions”. The American Journal of Pathology, Vol. 184, No. 7, July 2014

Background References

“Hyaluronic Acid: A key molecule in skin aging”. Papkonstantou E et el.DermoEndorcinology 4:3, 253-258 December 2012.

“Ultrastructural Analysis of Human Epidermal CD44 Reveals Preferential Distribution on Plasma Membrane Domains Facing the Hyaluronan-rich Matrix Pouches”. Anna-Liisa Tuhkanen, Markku Tammi, Alpo Pelttari, Ulla M. Ågren and Raija Tammi. J Histochem Cytochem 1998 46: 241.

“Identification of Hyaluronic Acid Binding Sites in the Extracellular Domain of CD44”.Robert J. Peach, Diane Hollenbaugh, Ivan Stamenkovic, and Alejandro Aruffo. The Journal of Cell Biology, Volume 122, Number 1, July 1993 257-264.

“The High and Low Molecular Weight Forms of Hyaluronan Have Distinct Effects on CD44 Clustering”. Cuixia Yang et al. THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 287, NO. 51, pp. 43094 –43107, December 14, 2012.

“Efficacy of a New Topical Nano-hyaluronic Acid in Humans”. S. Manjula Jegasothy, Valentina Zabolotniaia, and Stephan Bielfeldt. J Clin Aesthet Dermatol. 2014 Mar; 7(3): 27–29.

“Interaction of nanoparticles and cell-penetrating peptides with skin for transdermal drug delivery”. Pinaki Desai, Ram R. Patlolla, and Mandip Singh. Mol Membr Biol. 2010 Oct; 27(7): 247–259. doi: 10.3109/09687688.2010.522203.